Gas chromatography/mass spectrometry (GC/MS) is the preferred confirmatory method. A more specific alternate chemical method must be used in order to obtain a confirmed analytical result. This assay provides only a preliminary analytical test result. The results are summarized below.Ĭonfigurations of the One Step Drug Screen Test Card consist of combination of Methamphetamine Marijuana(THC) drug analytes. Elevated levels of urinary metabolites are found within hours of exposure and remain detectable for 3-10 days after smoking.Ī drug-free urine pool was spiked with drugs at concentrations listed. The peak effect of marijuana administered by smoking occurs in 20-30 minutes and the duration is 90-120 minutes after one cigarette. Long-term, relatively heavy use may be associated with behavioral disorders. They may also experience transient episodes of confusion and anxiety. Users have impaired short term memory and slow learning. When smoked or orally administered, THC produces euphoric effects. THC (∆9-tetrahydrocannabinol) is the primary active ingredient in cannabis (marijuana). The One Step Drug Screen Test Card yields a positive result when the Methamphetamine in urine exceeds 1,000 ng/mL. Methamphetamine is generally detectable in the urine for 3-5 days, depending on urine pH level. Thus, the presence of the parent compound in the urine indicates Methamphetamine use. However, 10-20% of Methamphetamine is excreted unchanged. Methamphetamine is excreted in the urine as amphetamine and oxidized and delaminated derivatives. The effects of Methamphetamine generally last 2-4 hours and the drug has a half-life of 9-24 hours in the body. More acute responses produce anxiety, paranoia, hallucinations, psychotic behavior, and eventually, depression and exhaustion. Cardiovascular responses to Methamphetamine include increased blood pressure and cardiac arrhythmias. Acute higher doses lead to enhanced stimulation of the central nervous system and induce euphoria, alertness, reduced appetite, and a sense of increased energy and power. The drug can be taken orally, injected, or inhaled. Methamphetamine is made in illegal laboratories and has a high potential for abuse and dependence. Methamphetamine is closely related chemically to amphetamine, but the central nervous system effects of Methamphetamine are greater. Methamphetamine is an addictive stimulant drug that strongly activates certain systems in the brain. Therefore, clinical laboratories should provide on request chiral analysis to aid in differentiating illicit and medicinal MAMP.The One Step Drug Screen Test Card is a lateral flow chromatographic immunoassay for the qualitative detection of multiple drugs such as Methamphetamine Marijuana(THC) drug metabolites in urine at the following cut-off concentrations: These data indicate that the use of both illicit and medicinal MAMP is found in this patient population, and that medicinal use is underreported in clinical histories. The prevalence of MAMP medications based on reported medications and detection of l-MAMP in Group 1 and Group 2 was 44% and 6%, respectively. The overall MAMP positivity rate of the 485,889 specimens tested was 1.6%. Group 2 contained randomly selected MAMP positive specimens. Group 1 contained specimens that were MAMP positive and amphetamine negative. Two groups of 100 specimens each were subjected to chiral analysis. This retrospective analysis included the LC-MS/MS results and prescriber provided medication histories of 485,889 de-identified urine specimens from patients treated for pain. The purpose of the study is to estimate the prevalence of medicinal and illicit MAMP in the pain population using chiral analysis to determine the relative amounts of the d and l-MAMP enantiomers. In addition to illicit methamphetamine, there are prescription and over-the-counter medications that, if ingested, may yield positive methamphetamine (MAMP) results on laboratory urine drug tests.
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